CA8 antibody (full length)

Catalog No. ABIN7877778

The Mouse Monoclonal anti-CA8 antibody is suitable to detect CA8 in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for CA8 antibody (full length) (ABIN7877778)

Target: CA8 (Carbonic Anhydrase VIII (CA8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CA8 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: CA8-6814

Product Details anti-CA8 Antibody

Binding Specificity: full length

Purpose: Carbonic Anhydrase VIII Antibody / CA8 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the Carbonic Anhydrase VIII antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the Carbonic Anhydrase VIII antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Carbonic Anhydrase VIII antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CA8

Target: CA8 (Carbonic Anhydrase VIII (CA8))

Alternative Name: Carbonic Anhydrase VIII

Background: The protein encoded by this gene was initially named CA-related protein because of sequence similarity to other known carbonic anhydrase genes. However, the gene product lacks carbonic anhydrase activity (i.e., the reversible hydration of carbon dioxide). The gene product continues to carry a carbonic anhydrase designation based on clear sequence identity to other members of the carbonic anhydrase gene family. The absence of CA8 gene transcription in the cerebellum of the lurcher mutant in mice with a neurologic defect suggests an important role for this acatalytic form. Mutations in CA8 gene causes neuropathology, such as ataxia, mild mental retardation and the predisposition to quadrupedal gait. It is also associated with the development of colorectal and lung cancers. Additionally, it is upregulated in various cancers.

UniProt: P35219