Recombinant CD59 antibody (full length)

Catalog No. ABIN7877931

The Mouse Monoclonal anti-CD59 antibody is suitable to detect CD59 in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant CD59 antibody (full length) (ABIN7877931)

Target: CD59

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD59 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RMACIF-7288

Product Details anti-CD59 Antibody

Binding Specificity: full length

Purpose: Recombinant CD59 Antibody

Purification: Protein A affinity

Immunogen: Recombinant human full-length CD59 protein was used as the immunogen for the recombinant CD59 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant CD59 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant CD59 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CD59

Target: CD59

Alternative Name: CD59

Background: Reacts with human CD59, a 20 kDa glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein (Workshop VI, Code N-L036). CD59 regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. CD59 is widely distributed on cells in all tissues. It inhibits formation of MAC, thus protecting cells from complement-mediated lysis. The expression of CD59 on erythrocytes is important for their survival. Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH). This MAb recognizes CD59 transfected cells. It is useful for study on GPI-anchored proteins, PNH and CD59 functions.

UniProt: P13987

Pathways: Complement System