Chp2 antibody (full length)

Catalog No. ABIN7877978

This Mouse Monoclonal antibody specifically detects Chp2 in WB and IF. It exhibits reactivity toward Human.

Quick Overview for Chp2 antibody (full length) (ABIN7877978)

Target: Chp2

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Chp2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Grade: Carrier-free

Clone: CPTC-CHP2-1

Product Details anti-Chp2 Antibody

Binding Specificity: full length

Purpose: CHP2 Antibody / Calcineurin B homologous protein 2 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Recombinant human full-length protein was used as the immunogen for the CHP2 antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the CHP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the CHP2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Chp2

Target: Chp2

Background: CHP2 (calcineurin B homologous protein 2), also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.

UniProt: O43745