CKM antibody (full length)

Catalog No. ABIN7878038

This Mouse Monoclonal antibody specifically detects CKM in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for CKM antibody (full length) (ABIN7878038)

Target: CKM (Creatine Kinase, Muscle (CKM))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CKM antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CKMM-3341

Product Details anti-CKM Antibody

Binding Specificity: full length

Purpose: Creatine Kinase M Antibody / CKM

Purification: Protein G affinity chromatography

Immunogen: Recombinant full-length CKM protein was used as the immunogen for the Creatine Kinase M antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the Creatine Kinase M antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Creatine Kinase M antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for CKM

Target: CKM (Creatine Kinase, Muscle (CKM))

Alternative Name: Creatine Kinase M

Background: T cell proliferation and lymphokine production are triggered by occupation of the TCR by antigen, followed by a costimulatory signal that is delivered by a ligand expressed on antigen presenting cells. The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells bind the homologous T cell receptors CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and CD28 and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31 % overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. SLAM is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. B7, also designated BB1, is another ligand or counter receptor for CD28 and CTLA-4 that is expressed on the antigen-presenting cell.

UniProt: P06732