CRYAB antibody (full length)

Catalog No. ABIN7878045

The Mouse Monoclonal anti-CRYAB antibody is suitable to detect CRYAB in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for CRYAB antibody (full length) (ABIN7878045)

Target: CRYAB (Crystallin, alpha B (CRYAB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CRYAB antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: CRYAB-7918

Product Details anti-CRYAB Antibody

Binding Specificity: full length

Purpose: Crystallin Alpha B Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant human full-length CRYAB protein was used as the immunogen for the Crystallin Alpha B antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Crystallin Alpha B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Crystallin Alpha B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CRYAB

Target: CRYAB (Crystallin, alpha B (CRYAB))

Alternative Name: Crystallin Alpha B

Background: Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into Alpha, Beta and Gamma families, and the Beta- and Gamma-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha-crystallins consist of three gene products, AlphaA-, AlphaB- and AlphaC-crystallin, which are members of the small heat shock protein family (HSP 20). Alpha-crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, Alpha-crystallins do not renature these proteins. Expression of AlphaA-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC). The human AlphaB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of AlphaB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy.

UniProt: P02511