DAXX antibody (full length)

Catalog No. ABIN7878116

This Mouse Monoclonal antibody specifically detects DAXX in IF and FACS. It exhibits reactivity toward Human.

Quick Overview for DAXX antibody (full length) (ABIN7878116)

Target: DAXX (Death-Domain Associated Protein (DAXX))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DAXX antibody is un-conjugated

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Grade: Carrier-free

Clone: PCRP-DAXX-6A8

Product Details anti-DAXX Antibody

Binding Specificity: full length

Purpose: Daxx Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human DAXX protein was used as the immunogen for the Daxx antibody.

Isotype: IgG2c

Application Details

Application Notes: Optimal dilution of the Daxx antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Daxx antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for DAXX

Target: DAXX (Death-Domain Associated Protein (DAXX))

Alternative Name: Daxx

Background: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

UniProt: Q9UER7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway