DAXX antibody (full length)

Catalog No. ABIN7878125

This Mouse Monoclonal antibody specifically detects DAXX in FACS and IHC (p). It exhibits reactivity toward Human.

Quick Overview for DAXX antibody (full length) (ABIN7878125)

Target: DAXX (Death-Domain Associated Protein (DAXX))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DAXX antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PCRP-DAXX-6E11

Product Details anti-DAXX Antibody

Binding Specificity: full length

Purpose: Death domain associated protein 6 Antibody / Daxx

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the Death domain associated protein 6 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the Death domain associated protein 6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Death domain associated protein 6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for DAXX

Target: DAXX (Death-Domain Associated Protein (DAXX))

Alternative Name: Death domain associated protein 6

Background: This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.

UniProt: Q9UER7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway