Desmin antibody (full length)

Catalog No. ABIN7878128

This Mouse Monoclonal antibody specifically detects Desmin in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Desmin antibody (full length) (ABIN7878128)

Target: Desmin (DES)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Desmin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: DES-4526

Product Details anti-Desmin Antibody

Binding Specificity: full length

Purpose: Desmin Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human desmin protein was used as the immunogen for the Desmin antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Desmin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Desmin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Desmin

Target: Desmin (DES)

Alternative Name: Desmin

Background: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain -helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles.Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

UniProt: P17661