Recombinant Desmin antibody (full length)

Catalog No. ABIN7878133

The Mouse Monoclonal anti-Desmin antibody (Clone rDES-8846) (ABIN7878133) specifically detects Desmin in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant Desmin antibody (full length) (ABIN7878133)

Target: Desmin (DES)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Desmin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RDES-8846

Product Details anti-Desmin Antibody

Binding Specificity: full length

Purpose: DES Antibody / Desmin

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human desmin protein was used as the immunogen for the DES antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the DES antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the DES antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Desmin

Target: Desmin (DES)

Alternative Name: DES

Background: Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain Alpha-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.

UniProt: P17661