E2F6 antibody (full length)

Catalog No. ABIN7878147

The Mouse Monoclonal anti-E2F6 antibody is suitable to detect E2F6 in samples from Human. It has been validated for IF and FACS.

Quick Overview for E2F6 antibody (full length) (ABIN7878147)

Target: E2F6 (E2F Transcription Factor 6 (E2F6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This E2F6 antibody is un-conjugated

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-E2F6-1F8

Product Details anti-E2F6 Antibody

Binding Specificity: full length

Purpose: E2F6 Antibody

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human E2F6 protein was used as the immunogen for the E2F6 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the E2F6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the E2F6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for E2F6

Target: E2F6 (E2F Transcription Factor 6 (E2F6))

Alternative Name: E2F6

Background: The human retinoblastoma gene product appears to play an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus encoded proteins. Of all the Rb associations described to date, the identification of a complex between Rb and the transcription factor E2F most directly implicates Rb in regulation of cell proliferation. E2F was originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Sequences homologous to the E2F binding site have been found upstream of a number of genes that encode proteins with putative functions in the G1and S phases of the cell cycle. E2F-1 is a member of a broader family of transcriptional regulators including E2F-2, E2F-3, E2F-4, E2F-5 and E2F-6, each of which forms heterodimers with a second protein, DP-1, forming an active E2F transcriptional regulatory complex.

UniProt: O75461