ECD/SGT1 antibody (full length)

Catalog No. ABIN7878150

The Mouse Monoclonal anti-ECD/SGT1 antibody is suitable to detect ECD/SGT1 in samples from Human. It has been validated for IF and FACS.

Quick Overview for ECD/SGT1 antibody (full length) (ABIN7878150)

Target: ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ECD/SGT1 antibody is un-conjugated

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Grade: Carrier-free

Clone: PCRP-ECD-1D10

Product Details anti-ECD/SGT1 Antibody

Binding Specificity: full length

Purpose: ECD Antibody / SGT1 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the ECD antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the ECD antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the ECD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for ECD/SGT1

Target: ECD/SGT1 (ECD) (Ecdysoneless Homolog (ECD))

Alternative Name: ECD

Background: Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.

UniProt: O95905

Pathways: Regulation of Carbohydrate Metabolic Process