Recombinant Fascin antibody (full length)

Catalog No. ABIN7878217

The Mouse Monoclonal anti-Fascin antibody (Clone rFSCN1-6464) (ABIN7878217) specifically detects Fascin in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant Fascin antibody (full length) (ABIN7878217)

Target: Fascin (FSCN1)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Fascin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: RFSCN1-6464

Product Details anti-Fascin Antibody

Binding Specificity: full length

Purpose: Recombinant FSCN1 Antibody / Fascin 1 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Full length recombinant human protein was used as the immunogen for the recombinant FSCN1 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the recombinant FSCN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the recombinant FSCN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Fascin

Target: Fascin (FSCN1)

Alternative Name: FSCN1

Background: Recognizes a protein of 55 kDa, which is identified as Fascin-1. Its actin binding ability is regulated by phosphorylation. Antibody to fascin-1 is a very sensitive marker for Reed-Sternberg cells and variants in nodular sclerosis, mixed cellularity, and lymphocyte depletion Hodgkin's disease. It is uniformly negative in lymphoid cells, plasma cells, and myeloid cells. Fascin-1 is also expressed in dendritic cells. This marker may be helpful to distinguish between Hodgkin lymphoma and non-Hodgkin lymphoma in difficult cases. Also, the lack of expression of fascin-1 in the neoplastic follicles in follicular lymphoma may be helpful in distinguishing these lymphomas from reactive follicular hyperplasia in which the number of follicular dendritic cells is normal or increased. Antibody to fascin-1 has been suggested as a prognostic marker in neuroendocrine neoplasms of the lung as well as in ovarian cancer. Fascin-1 expression may be induced by Epstein-Barr virus (EBV) infection of B cells with the possibility that viral induction of fascin in lymphoid or other cell types must also be considered in EBV-positive cases.

UniProt: Q16658