GPN1 antibody (full length)

Catalog No. ABIN7878316

The Mouse Monoclonal anti-GPN1 antibody (Clone GPN1-2350) (ABIN7878316) specifically detects GPN1 in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for GPN1 antibody (full length) (ABIN7878316)

Target: GPN1 (GPN-Loop GTPase 1 (GPN1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GPN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Grade: Carrier-free

Clone: GPN1-2350

Product Details anti-GPN1 Antibody

Binding Specificity: full length

Purpose: XAB1 Antibody / GPN1 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Recombinant full length human protein was used as the immunogen for this XAB1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the XAB1 antibody to be titered up or down for optimal performance.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the XAB1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for GPN1

Target: GPN1 (GPN-Loop GTPase 1 (GPN1))

Alternative Name: XAB1

Background: GPN1 (GPN-loop GTPase 1), also called XAB1 (XPA-binding protein 1) is involved in protein synthesis events. It is expressed ubiquitously with highest expression in testis. It binds to the RNA polymerase II- (Poll II) associated proteins RPAP1-3 and to XPA (a protein involved in DNA repair mechanisms), thereby forming an interface with Poll II. Via this interaction, GPN1 is thought to mediate the involvement of Pol II in both protein complex formation and protein chaperone/ scaffolding activities. In addition, GPN1 interacts with components of the integrator and molecular chaperone complexes, further implicating it in protein assembly. GPN1 contains a cluster of acidic amino acids in its C-terminal region and a series of sequences similar to those found in GTP-binding proteins in its N-terminal region, suggesting that it has possible GTPase activity.

UniProt: Q9HCN4