HDAC7 antibody (full length)

Catalog No. ABIN7878381

The Mouse Monoclonal anti-HDAC7 antibody is suitable to detect HDAC7 in samples from Human. It has been validated for FACS.

Quick Overview for HDAC7 antibody (full length) (ABIN7878381)

Target: HDAC7 (Histone Deacetylase 7 (HDAC7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HDAC7 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Grade: Carrier-free

Clone: PCRP-HDAC7-1B6

Product Details anti-HDAC7 Antibody

Binding Specificity: full length

Purpose: HDAC7 Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the HDAC7 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the HDAC7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the HDAC7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for HDAC7

Target: HDAC7 (Histone Deacetylase 7 (HDAC7))

Alternative Name: HDAC7

Background: In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC7 is a histone deacetylase that interacts with the adaptor mSin3A. The interaction of HDAC7 with mSin3A suggests the association of multiple repression complexes of transcription factors.

UniProt: Q8WUI4

Pathways: Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development