IRF3 antibody (full length)

Catalog No. ABIN7878439

The Mouse Monoclonal anti-IRF3 antibody (Clone PCRP-IRF3-6C8) (ABIN7878439) specifically detects IRF3 in WB, IF and FACS. The antibody is reactive with Human samples.

Quick Overview for IRF3 antibody (full length) (ABIN7878439)

Target: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IRF3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-IRF3-6C8

Product Details anti-IRF3 Antibody

Binding Specificity: full length

Purpose: IRF3 Antibody / Interferon regulatory factor 3

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human IRF3 protein was used as the immunogen for the IRF3 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the IRF3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the IRF3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IRF3

Target: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Alternative Name: IRF3

Background: In the absence of viral infection, IRF3 is maintained as a monomer in an autoinhibited state. Phosphorylation by TBK1 and IKBKE disrupts this autoinhibition leading to the liberation of the DNA-binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes. [UniProt]

UniProt: Q14653

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades