IRF3 antibody (full length)

Catalog No. ABIN7878449

This Mouse Monoclonal antibody specifically detects IRF3 in FACS and IHC (p). It exhibits reactivity toward Human.

Quick Overview for IRF3 antibody (full length) (ABIN7878449)

Target: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IRF3 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PCRP-IRF3-4D7

Product Details anti-IRF3 Antibody

Binding Specificity: full length

Purpose: Interferon regulatory factor 3 Antibody / IRF3

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human IRF3 protein was used as the immunogen for the Interferon regulatory factor 3 antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the Interferon regulatory factor 3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Interferon regulatory factor 3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IRF3

Target: IRF3 (Interferon Regulatory Factor 3 (IRF3))

Alternative Name: Interferon regulatory factor 3

Background: Interferon regulatory factor-1 (IRF-1) and IRF-2 have been identified as novel DNA-binding factors that function as regulators of both type I interferon (interferon-Alpha and beta) and interferon-inducible genes. The two factors are structurally related, particularly in their N-terminal regions, which confer DNA binding specificity. In addition, both bind to the same sequence within the promoters of interferon-Alpha and interferon-beta genes. IRF-1 functions as an activator of interferon transcription, while IRF-2 binds to the same cis elements and represses IRF-1 action. IRF-1 and IRF-2 have been reported to act in a mutually antagonistic manner in regulating cell growth, overexpression of the repressor IRF-2 leads to cell transformation while concomitant overexpression of IRF-1 causes reversion. IRF-1 and IRF-2 are members of a larger family of DNA binding proteins that includes IRF-3, IRF-4, IRF-5, IRF-6, IRF-7, ISGF-3gammap48 and IFN consensus sequence-binding protein (ICSBP).

UniProt: Q14653

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades