IL-4 antibody (full length)

Catalog No. ABIN7878458

This Mouse Monoclonal antibody specifically detects IL-4 in ELISA. It exhibits reactivity toward Human.

Quick Overview for IL-4 antibody (full length) (ABIN7878458)

Target: IL-4 (IL4) (Interleukin 4 (IL4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-4 antibody is un-conjugated

Application: ELISA

Grade: Carrier-free

Clone: IL4-1597

Product Details anti-IL-4 Antibody

Binding Specificity: full length

Purpose: Interleukin 4 Antibody / IL-4 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Recombinant full-length human IL-4 protein was used as the immunogen for this Interleukin 4 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Interleukin 4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Interleukin 4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for IL-4

Target: IL-4 (IL4) (Interleukin 4 (IL4))

Alternative Name: Interleukin 4

Background: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin.

UniProt: P07750

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation