Keratin 6B antibody (full length)

Catalog No. ABIN7878504

The Mouse Monoclonal anti-Keratin 6B antibody is suitable to detect Keratin 6B in samples from Human. It has been validated for IHC (p).

Quick Overview for Keratin 6B antibody (full length) (ABIN7878504)

Target: Keratin 6B (KRT6B)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Keratin 6B antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: KRT6B-2116

Product Details anti-Keratin 6B Antibody

Binding Specificity: full length

Purpose: Cytokeratin 6B Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Recombinant full-length human KRT6B protein was used as the immunogen for the Cytokeratin 6B antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the Cytokeratin 6B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Cytokeratin 6B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Keratin 6B

Target: Keratin 6B (KRT6B)

Alternative Name: Cytokeratin 6B

Background: This MAb recognizes a protein of 56 kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75 % of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.

UniProt: P04259