KDM5C antibody (full length)

Catalog No. ABIN7878544

The Mouse Monoclonal anti-KDM5C antibody (Clone PCRP-KDM5C-1A11) (ABIN7878544) specifically detects KDM5C in FACS. The antibody is reactive with Human samples.

Quick Overview for KDM5C antibody (full length) (ABIN7878544)

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KDM5C antibody is un-conjugated

Application: Flow Cytometry (FACS)

Grade: Carrier-free

Clone: PCRP-KDM5C-1A11

Product Details anti-KDM5C Antibody

Binding Specificity: full length

Purpose: JARID1C Antibody / KDM5C / SMCX (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the JARID1C antibody.

Isotype: IgG2c

Application Details

Application Notes: Optimal dilution of the JARID1C antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the JARID1C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for KDM5C

Target: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Alternative Name: JARID1C

Background: SmcX, also known as JARID1C (jumonji, AT rich interactive domain 1C), MRXJ, KDM5C or XE169, is a nuclear protein that contains one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers and belongs to the JARID1 histone demethylase family. Expressed ubiquitously with highest expression in brain and skeletal muscle, SmcX functions as a histone demethylase that removes methyl groups from lysine residues on Histone H3, thereby playing a role in the histone code, as well as transcriptional regulation and chromatin remodeling. SmcX binds iron and a-ketoglutarate as cofactors and can recruit histone deacetylases to neuron silencer elements, thus repressing the transcription of neuronal genes. Defects in the gene encoding SmcX are associated with X-linked mental retardation (XLMR), a condition characterized by cognitive impairment and a low IQ. Multiple isoforms of SmcX are expressed due to alternative splicing events.

UniProt: P41229

Pathways: Warburg Effect