MLX antibody (full length)

Catalog No. ABIN7878588

The Mouse Monoclonal anti-MLX antibody is suitable to detect MLX in samples from Human. It has been validated for WB, IF and FACS.

Quick Overview for MLX antibody (full length) (ABIN7878588)

Target: MLX (MAX-Like Protein X (MLX))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MLX antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Grade: Carrier-free

Clone: PCRP-MLX-1G8

Product Details anti-MLX Antibody

Binding Specificity: full length

Purpose: MLX Antibody / Max-like protein X (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human MLX protein was used as the immunogen for the MLX antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the MLX antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the MLX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for MLX

Target: MLX (MAX-Like Protein X (MLX))

Alternative Name: MLX

Background: Max is a nuclear localized bHLH-Zip protein that forms homodimers or heterodimers with Myc family members, including Myc, Mad1, Mad3, Mad4, Mxi1 and Mnt (or Rox). These dimers bind to the E-box sequence CACGTG in order to regulate cell growth, proliferation and apoptosis. Mlx (Max-like protein X) is a bHLH-Zip protein that is structurally and functionally related to Max. Like Max, Mlx is broadly expressed in many tissues and has a long half-life. Mlx also forms homodimers or heterodimers with members of the Myc family, specifically Mad1, Mad4 and Rox, and members of the Mondo family, to repress or activate transcription from CACGTG E-boxes. MondoA forms weak homodimers and preferentially forms heterodimers with Mlx. The MondoA/Mlx complex is primarily localized to the cytoplasm, but will translocate to the nucleus in response to leptomycin B. Mlx can also dimerize with WBSCR14, a protein involved in Williams-Beuren syndrome (WBS), to repress E-box transcription, which provides further evidence that Mlx is a critical element in a transcription factor network.

UniProt: Q9UH92