MTF1 antibody (full length)

Catalog No. ABIN7878611

This Mouse Monoclonal antibody specifically detects MTF1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for MTF1 antibody (full length) (ABIN7878611)

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MTF1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: MTF1-2649

Product Details anti-MTF1 Antibody

Binding Specificity: full length

Purpose: MTF1 Antibody / Metal regulatory transcription factor 1 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A recombinant full-length human protein was used as the immunogen for the MTF1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the MTF1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the MTF1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for MTF1

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Alternative Name: MTF1

Background: The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing.

UniProt: Q14872