MTF1 antibody (full length)

Catalog No. ABIN7878612

The Mouse Monoclonal anti-MTF1 antibody is suitable to detect MTF1 in samples from Human. It has been validated for IHC (p).

Quick Overview for MTF1 antibody (full length) (ABIN7878612)

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MTF1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MTF1-2649

Product Details anti-MTF1 Antibody

Binding Specificity: full length

Purpose: MTF1 Antibody / Metal regulatory transcription factor 1

Purification: Protein G affinity chromatography

Immunogen: A recombinant full-length human protein was used as the immunogen for the MTF1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the MTF1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the MTF1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for MTF1

Target: MTF1 (Metal-Regulatory Transcription Factor 1 (MTF1))

Alternative Name: MTF1

Background: The metal-responsive element (MRE)-binding transcription factor (MTF-1) stimulates the expression of metallothioneins in response to the exposure of cells to heavy metals. MTF-1 contains six zinc fingers in the DNA binding domain. The phosphorylation of MTF-1 in response to metal exposure appears to play a significant role in the ability of MTF-1 to activate metallothionein transcription. In addition to its role in metallothionein activation, MTF-1 is involved in a post-transcription regulatory complex for ribosomal protein S25. MTF-1, La and p53 inhibit the nuclear export of S25 mRNA in response to nutrient depravation. Furthermore, MTF-1 acts as a chromatin insulator on integrated transgenes in cultured cells to insulate active loci against chromatin silencing.

UniProt: Q14872