NME1 antibody (full length)

Catalog No. ABIN7878717

The Mouse Monoclonal anti-NME1 antibody is suitable to detect NME1 in samples from Human. It has been validated for WB.

Quick Overview for NME1 antibody (full length) (ABIN7878717)

Target: NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NME1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: CPTC-NME1-2

Product Details anti-NME1 Antibody

Binding Specificity: full length

Purpose: NME1 Antibody / NM23

Purification: Protein G affinity chromatography

Immunogen: A recombinant full-length human NME1 protein was used as the immunogen for this NME1 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the NME1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the NME1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for NME1

Target: NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))

Alternative Name: NME1

Background: The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP-K). In humans, NDP kinase A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human C-Myc promotor.

UniProt: P15531

Pathways: Apoptosis, Nucleotide Phosphorylation, Carbohydrate Homeostasis, Ribonucleoside Biosynthetic Process