PMS1 antibody (full length)

Catalog No. ABIN7878820

The Mouse Monoclonal anti-PMS1 antibody (Clone PCRP-PMS1-2E11) (ABIN7878820) specifically detects PMS1 in ELISA, IF and FACS. The antibody is reactive with Human samples.

Quick Overview for PMS1 antibody (full length) (ABIN7878820)

Target: PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PMS1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-PMS1-2E11

Product Details anti-PMS1 Antibody

Binding Specificity: full length

Purpose: PMS1 Antibody / PMS1 protein homolog 1

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human PMS1 protein was used as the immunogen for the PMS1 antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the PMS1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the PMS1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PMS1

Target: PMS1 (PMS1 Postmeiotic Segregation Increased 1 (S. Cerevisiae) (PMS1))

Alternative Name: PMS1

Background: The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.

UniProt: P54277