POU1F1 antibody (full length)

Catalog No. ABIN7878832

The Mouse Monoclonal anti-POU1F1 antibody (Clone PIT1-7262) (ABIN7878832) specifically detects POU1F1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for POU1F1 antibody (full length) (ABIN7878832)

Target: POU1F1 (POU Class 1 Homeobox 1 (POU1F1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This POU1F1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PIT1-7262

Product Details anti-POU1F1 Antibody

Binding Specificity: full length

Purpose: POU1F1 Antibody / PIT-1 / GHF-1

Purification: Protein A/G affinity

Immunogen: Recombinant human full-length protein was used as the immunogen for the POU1F1 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the POU1F1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the POU1F1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for POU1F1

Target: POU1F1 (POU Class 1 Homeobox 1 (POU1F1))

Alternative Name: POU1F1

Background: Transcriptional regulators play a critical role in development by mediating tissue- and cell-specific transcription. POU domain factors are transcriptional regulators characterized by a bipartite DNA binding domain, which consists of two highly conserved regions, tethered by a variable linker of 14-26 amino acids. Pit-1, also known as growth hormone factor-1 (GHF-1), a member of the POU homeodomain family, is essential for the normal development of the anterior pituitary gland, where it is required for the formation of somatotropes, lactotropes and thyrotropes. In somatotropes and lactotropes, Pit-1 activates the production of growth hormone and Prolactin, respectively. In addition, Pit-1 acts as a repressor of gene expression, which allows for the differentiation of specific cell types. Pit-1 is expressed as two alternatively spliced products, designated Pit-1a and Pit-1b, which differ in their trans-activation ability. Mutations in the Pit-1 gene are believed to result in combined pituitary hormone deficiency (CPHD) for growth hormone, Prolactin and thyroid stimulating hormone. The gene which encodes Pit-1 maps to human chromosome 3p11.2.

UniProt: P28069

Pathways: Regulation of Carbohydrate Metabolic Process