SATB1 antibody (full length)

Catalog No. ABIN7878975

The Mouse Monoclonal anti-SATB1 antibody is suitable to detect SATB1 in samples from Human. It has been validated for IHC (p).

Quick Overview for SATB1 antibody (full length) (ABIN7878975)

Target: SATB1 (SATB Homeobox 1 (SATB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SATB1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SATB1-2661

Product Details anti-SATB1 Antibody

Binding Specificity: full length

Purpose: SATB1 Antibody / Special AT-rich sequence-binding protein 1

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human SATB1 protein was used as the immunogen for the SATB1 antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the SATB1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SATB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for SATB1

Target: SATB1 (SATB Homeobox 1 (SATB1))

Alternative Name: SATB1

Background: The homeoproteins CCAAT displacement protein (CDP) and special AT-rich sequence binding protein 1 (SATB1) are transcriptional repressors of many cellular genes, and they participate in cell development and cell type differentiation. SATB1 is expressed primarily in thymocytes, and, like CDP, it also contains a distinct homeobox DNA-binding domain that is essential for DNA binding. SATB1 and CDP interact through these homeodomains and synergistically function as mediators of gene expression. SATB1 contains an additional domain that has a higher affinity for DNA and specifically facilitates the direct association between SATB1 and the nuclear matrix attachment regions (MARs) of DNA. MARs are specific DNA sequences that bind to the nuclear matrix and form the base of chromosomal loops that organize the chromosomes and regulate DNA transcription and replication within the nucleus. The association of SATB1 with the core unwinding element within the base-unpairing region of MARs requires both the MAR and homeobox binding domains of SATB1.

UniProt: Q01826

Pathways: Caspase Cascade in Apoptosis, Activated T Cell Proliferation