SCXA antibody (full length)

Catalog No. ABIN7878977

This Mouse Monoclonal antibody specifically detects SCXA in FACS and IF. It exhibits reactivity toward Human.

Quick Overview for SCXA antibody (full length) (ABIN7878977)

Target: SCXA (Scleraxis (SCXA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SCXA antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: PCRP-SCXA-2D11

Product Details anti-SCXA Antibody

Binding Specificity: full length

Purpose: SCXA Antibody / Scleraxis

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human Basic helix-loop-helix transcription factor scleraxis protein was used as the immunogen for the SCXA antibody.

Isotype: IgG2a

Application Details

Application Notes: Optimal dilution of the SCXA antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SCXA antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for SCXA

Target: SCXA (Scleraxis (SCXA))

Alternative Name: SCXA

Background: Transcription factors are proteins that bind DNA adjacent to genes and control the production of mRNA transcripts. Scleraxis (basic helix-loop-helix transcription factor scleraxis) is a 201 amino acid protein that dimerizes with another bHLH protein to initiate transcription. Scleraxis is known to play a role in formation of mesoderm and somite-derived chondrogenic lineages. Scleraxis localizes to the nucleus and contains one bHLH domain. bHLH transcription factors, in general, function in cellular differentiation, proliferation, and oncogene regulation. The gene encoding Scleraxis maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to chromosome 8.

UniProt: Q7RTU7