SIRT2 antibody (full length)

Catalog No. ABIN7879049

This Mouse Monoclonal antibody specifically detects SIRT2 in WB, IF and FACS. It exhibits reactivity toward Human.

Quick Overview for SIRT2 antibody (full length) (ABIN7879049)

Target: SIRT2 (Sirtuin 2 (SIRT2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIRT2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Grade: Carrier-free

Clone: PCRP-SIRT2-1A8

Product Details anti-SIRT2 Antibody

Binding Specificity: full length

Purpose: Sirtuin 2 Antibody / SIRT2 (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human SIRT2/Sirtuin 2 protein was used as the immunogen for the Sirtuin 2 antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the Sirtuin 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Sirtuin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for SIRT2

Target: SIRT2 (Sirtuin 2 (SIRT2))

Alternative Name: Sirtuin 2

Background: The silent information regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in a NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologs, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT proteins may function via mono-ADP-ribosylation of proteins. SIRT2 contains a 323 amino acid catalytic core domain with a NAD-binding domain and a large groove which is the likely site of catalysis.

UniProt: Q8IXJ6