SIRT3 antibody (full length)

Catalog No. ABIN7879052

This Mouse Monoclonal antibody specifically detects SIRT3 in WB, ELISA, IF and FACS. It exhibits reactivity toward Human.

Quick Overview for SIRT3 antibody (full length) (ABIN7879052)

Target: SIRT3 (Sirtuin 3 (SIRT3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIRT3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-SIRT3-1C10

Product Details anti-SIRT3 Antibody

Binding Specificity: full length

Purpose: SIRT3 Antibody

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human SIRT3 protein was used as the immunogen for the SIRT3 antibody.

Isotype: IgG2a

Application Details

Application Notes: Optimal dilution of the SIRT3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the SIRT3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for SIRT3

Target: SIRT3 (Sirtuin 3 (SIRT3))

Alternative Name: SIRT3

Background: Zinc-fingers and homeobox (ZHX) proteins are transcription factors that interact with the activation domain of the A subunit of nuclear factor-Y (NF-YA). ZHX1-3 are ubiquitously expressed proteins expressed in various tissues. They act as transcriptional repressors and localize to the nucleus. The ZHX proteins contain two Cys2-His2-type zinc-finger motifs and five homeodomains (HDs). These domains allow the ZHX proteins to form homodimers, but they can also form heterodimers with each other. However, this dimerization is not required for repressor activity. Hypermethylation-mediated silencing of ZHX2 is an epigenetic event involved in hepatocellular carcinoma (HCC).

UniProt: Q9NTG7