Recombinant Smoothelin antibody (full length)

Catalog No. ABIN7879066

The Rabbit Monoclonal anti-Smoothelin antibody (Clone SMTN-2320R) (ABIN7879066) specifically detects Smoothelin in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant Smoothelin antibody (full length) (ABIN7879066)

Target: Smoothelin (SMTN)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Smoothelin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SMTN-2320R

Product Details anti-Smoothelin Antibody

Binding Specificity: full length

Purpose: Recombinant Smoothelin Antibody / SMSMO / SMTN

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human protein was used as the immunogen for the recombinant Smoothelin antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Smoothelin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant Smoothelin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Smoothelin

Target: Smoothelin (SMTN)

Alternative Name: Smoothelin

Background: Smoothelin is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. In the vascular system, smoothelin expression is limited to large veins and arteries capable of pulsatile contraction. As a marker for the highly differentiated contractile smooth muscle cell, smoothelin expression is useful for studying vascular malformation and injury. It is a constituent of the smooth muscle cell cytoskeleton protein exclusively found in differentiated smooth muscle cells (SMC). Cells with SMC-like characteristics, such as myofibroblasts and myoepithelial cells, as well as skeletal and cardiac muscle do not contain smoothelin.To distinguish bladder muscularis mucosae (MM) from muscularis propria (MP) muscle bundles is crucial for accurate staging of bladder carcinoma. Strong smoothelin expression is nearly exclusively observed in muscularis propria. Therefore, the staining pattern of MP (strongly positive) and MM (negative or weakly positive) makes this antibody an attractive diagnostic tool. Anti-smoothelin immunostaining can be helpful in differentiating benign (+) from malignant smooth muscle tumors (-), and other mimics (-).

UniProt: P53814