SOX4 antibody (full length)

Catalog No. ABIN7879075

The Mouse Monoclonal anti-SOX4 antibody (Clone SOX4-2540) (ABIN7879075) specifically detects SOX4 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for SOX4 antibody (full length) (ABIN7879075)

Target: SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SOX4 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: SOX4-2540

Product Details anti-SOX4 Antibody

Binding Specificity: full length

Purpose: SOX4 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Full length recombinant human protein was used as the immunogen for the SOX4 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the SOX4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the SOX4 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for SOX4

Target: SOX4 (SRY (Sex Determining Region Y)-Box 4 (SOX4))

Alternative Name: SOX4

Background: SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors with a critical role in embryonic development and in cell-fate determination during organogenesis of the heart, pancreas, brain, and in B and T lymphocyte differentiation. SOX4 gene expression is upregulated in many cancer types, and increased SOX4 activity contributes to cellular transformation, cell survival, and metastasis. Gene expression profiling has uncovered SOX4 with upregulated activity during TGF-AŽ ²-induced epithelial-mesenchymal transition (EMT) in normal and cancerous breast epithelial cells. SOX4 is indispensable for EMT and cell survival in vitro and for primary tumor growth and metastasis in vivo. SOX4 is identified as a master regulator of EMT by governing the expression of the epigenetic modifier Ezh2.

UniProt: Q06945