TAL1 antibody (full length)

Catalog No. ABIN7879110

The Mouse Monoclonal anti-TAL1 antibody is suitable to detect TAL1 in samples from Human. It has been validated for WB.

Quick Overview for TAL1 antibody (full length) (ABIN7879110)

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TAL1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: BTL73

Product Details anti-TAL1 Antibody

Binding Specificity: full length

Purpose: TAL1 Antibody / T-cell acute lymphocytic leukemia protein 1

Purification: Protein G affinity chromatography

Immunogen: A recombinant human full-length TAL1 protein was used as the immunogen for the TAL1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the TAL1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the TAL1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for TAL1

Target: TAL1 (T-Cell Acute Lymphocytic Leukemia 1 (TAL1))

Alternative Name: TAL1

Background: Activation of TAL1 characterizes up to 60 % of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIHLH transcription factors.

UniProt: P17542

Pathways: Stem Cell Maintenance