CD1c antibody (full length)

Catalog No. ABIN7879116

The Mouse Monoclonal anti-CD1c antibody is suitable to detect CD1c in samples from Human. It has been validated for ELISA.

Quick Overview for CD1c antibody (full length) (ABIN7879116)

Target: CD1c (CD1C) (T-cell surface glycoprotein CD1c (CD1C))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD1c antibody is un-conjugated

Application: ELISA

Clone: CD1C-1603

Product Details anti-CD1c Antibody

Binding Specificity: full length

Purpose: CD1c Antibody

Purification: Protein G affinity chromatography

Immunogen: A recombinant full-length human CD1c protein was used as the immunogen for this CD1c antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CD1c antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the CD1c antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for CD1c

Target: CD1c (CD1C) (T-cell surface glycoprotein CD1c (CD1C))

Alternative Name: CD1c

Background: The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. CD1 antigens are associated with -2-Microglobulin and expressed on cortical thymocytes, Langerhans cells, a B cell subset and some dendritic cells. Specifically, CD1A is a marker for Langerhans cell histiocytosis (LCH) and is found on interdigitating cells. Adaptor-protein complexes and CD1-associated chaperones control CD1 trafficking, and the development and activation of CD1-restricted T cells. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells. The human CD1 genes are all closely linked in a cluster mapping at chromosome 1q23.1

UniProt: P29017