Transglutaminase 2 antibody (full length)

Catalog No. ABIN7879184

This Mouse Monoclonal antibody specifically detects Transglutaminase 2 in IF, IHC (p) and FACS. It exhibits reactivity toward Human.

Quick Overview for Transglutaminase 2 antibody (full length) (ABIN7879184)

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Transglutaminase 2 antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Grade: Carrier-free

Clone: TGM2-3612

Product Details anti-Transglutaminase 2 Antibody

Binding Specificity: full length

Purpose: Transglutaminase 2 Antibody (FN Binding Domain) (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human TGM2 protein was used as the immunogen for the Transglutaminase 2 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Transglutaminase 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Handling Advice: Avoid repeated freeze-thaw cycles

Storage: -20 °C

Storage Comment: Aliquot the Transglutaminase 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Transglutaminase 2

Target: Transglutaminase 2 (TGM2) (Transglutaminase 2 (C Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM2))

Alternative Name: Transglutaminase 2

Background: Tissue transglutaminase (tTG) is a 75 kDa monomeric globular protein expressed in the majority of cells and tissues. tTG localizes mainly in the cytoplasm but some tGT is present on the cell surface and is association with the extracellular matrix. In addition to its guanosine triphosphatase (GTPase) activity, tTG catalyzes the posttranslational modification of proteins by transamidation of available glutamine residues. Extracellular tTG is able to bind to and cross-link several ECM proteins including FN/Fibronectin and SPP1, and may function to stabilize the ECM and basement membranes. The protein is translated as a fully active enzyme and there is no evidence for proteolytic activation. High constitutive expression and accumulation of active tTG is observed in (among others) endothelial cells, platelets, vascular smooth muscle cells and epithelial cells of the lens. tTG is expressed at very low levels in skeletal muscle cells and neurons and may be difficult to detect in these cell/tissue types.

UniProt: P21980

Pathways: Tube Formation, Thromboxane A2 Receptor Signaling