ZBTB46 antibody (full length)

Catalog No. ABIN7879350

The Mouse Monoclonal anti-ZBTB46 antibody is suitable to detect ZBTB46 in samples from Human. It has been validated for WB, IF, FACS and IHC (p).

Quick Overview for ZBTB46 antibody (full length) (ABIN7879350)

Target: ZBTB46 (ZNF340) (Zinc Finger Protein 340 (ZNF340))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ZBTB46 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PCRP-ZBTB46-2B8

Product Details anti-ZBTB46 Antibody

Binding Specificity: full length

Purpose: ZBTB46 Antibody / BTBD4 / ZNF340

Purification: Protein A/G affinity

Immunogen: Recombinant full-length human Zinc finger and BTB domain-containing protein 46 protein was used as the immunogen for the ZBTB46 antibody.

Isotype: IgG2a

Application Details

Application Notes: Optimal dilution of the ZBTB46 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the ZBTB46 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for ZBTB46

Target: ZBTB46 (ZNF340) (Zinc Finger Protein 340 (ZNF340))

Alternative Name: ZBTB46

Background: BTBD4 (BTB/POZ domain-containing protein 4), also known as zinc finger protein 340 (ZNF340) or zinc finger and BTB domain-containing protein 46 (ZBTB46), is a 589 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ inter- actions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this tran- scriptional repression is attenuated. This suggests that BTBD4 may play a role in transcription regulation.

UniProt: Q86UZ6