ZFYVE28 antibody (full length)

Catalog No. ABIN7879378

The Mouse Monoclonal anti-ZFYVE28 antibody (Clone LST2-2426) (ABIN7879378) specifically detects ZFYVE28 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for ZFYVE28 antibody (full length) (ABIN7879378)

Target: ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ZFYVE28 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: LST2-2426

Product Details anti-ZFYVE28 Antibody

Binding Specificity: full length

Purpose: ZFYVE28 Antibody

Purification: Protein G affinity chromatography

Immunogen: A recombinant full-length human protein was used as the immunogen for this ZFYVE28 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the ZFYVE28 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the ZFYVE28 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for ZFYVE28

Target: ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))

Alternative Name: ZFYVE28

Background: ZFYVE28 belongs to the lst-2 family. It contains 1 FYVE-type zinc finger. The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not mono-ubiquitinated at Lys-87. Mono-ubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. ZFYVE28 is a negative regulator of epidermal growth factor receptor (EGFR) signaling. It acts by promoting EGFR degradation in endosomes when not mono-ubiquitinated. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs.

UniProt: Q9HCC9

Pathways: EGFR Signaling Pathway