BMPR1A antibody (Middle Region)

Catalog No. ABIN7879508

This Rabbit Polyclonal antibody specifically detects BMPR1A in WB, IHC and FACS. It exhibits reactivity toward Human and Rat.

Quick Overview for BMPR1A antibody (Middle Region) (ABIN7879508)

Target: BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BMPR1A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Product Details anti-BMPR1A Antibody

Binding Specificity: Middle Region

Purpose: BMPR1A Antibody / Bone morphogenetic protein receptor type-1A

Purification: Immunogen affinity purified

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human BMPR1A was used as the immunogen for the BMPR1A antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the BMPR1A antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the BMPR1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for BMPR1A

Target: BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))

Alternative Name: BMPR1A

Background: BMPR1A antibody detects Bone morphogenetic protein receptor type-1A, encoded by the BMPR1A gene on chromosome 10q23.2. BMPR1A antibody is widely used in developmental biology, cancer research, and studies of TGF-beta superfamily signaling. BMPR1A is a transmembrane serine/threonine kinase receptor that mediates signaling by bone morphogenetic proteins (BMPs), which regulate embryogenesis, organogenesis, and tissue homeostasis. By transmitting extracellular BMP signals to intracellular Smad pathways, BMPR1A influences cell growth, apoptosis, and differentiation.

Structurally, BMPR1A is a ~60 kDa glycoprotein composed of an extracellular ligand-binding domain, a single-pass transmembrane segment, and an intracellular serine/threonine kinase domain. Upon ligand binding, BMPR1A forms a heteromeric complex with type II BMP receptors, which phosphorylate BMPR1A, activating its kinase domain. Activated BMPR1A phosphorylates receptor-regulated Smads (Smad1, Smad5, Smad8), which then translocate to the nucleus to regulate gene transcription.

Functionally, BMPR1A regulates bone and cartilage development, reproductive function, vascular remodeling, and stem cell differentiation. In the gut, BMPR1A signaling contributes to epithelial homeostasis and tumor suppression. Researchers use BMPR1A antibody to study BMP signaling in development, stem cells, and cancer models.

Clinically, mutations in BMPR1A cause juvenile polyposis syndrome, an inherited disorder characterized by gastrointestinal polyps and increased cancer risk. Germline mutations or deletions in BMPR1A disrupt BMP signaling, contributing to abnormal proliferation. Altered BMPR1A expression has also been reported in colorectal, gastric, and breast cancers. Targeting BMP signaling is under exploration for regenerative medicine and oncology. NSJ Bioreagents provides BMPR1A antibody for signaling, developmental, and cancer research.

Experimentally, BMPR1A antibody is used in western blotting to detect the ~60 kDa receptor, in immunohistochemistry to assess tissue expression, and in immunofluorescence microscopy to visualize membrane localization. Co-immunoprecipitation with BMPR1A antibody helps identify receptor complexes and Smad-binding partners.

UniProt: P36894

Pathways: Stem Cell Maintenance