Recombinant ACTH antibody (N-Term)

Catalog No. ABIN7879552

The Mouse Monoclonal anti-ACTH antibody (Clone rCLIP-1407) (ABIN7879552) specifically detects ACTH in IHC (p). The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Recombinant ACTH antibody (N-Term) (ABIN7879552)

Target: ACTH (Adrenocorticotropic hormone (ACTH))

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This ACTH antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: RCLIP-1407

Product Details anti-ACTH Antibody

Binding Specificity: N-Term

Purpose: Recombinant ACTH Antibody (CLIP polypeptide) (azide and preservative free)

Sequence: NGAEDESAEA FPLEF

Purification: Protein A/G affinity

Immunogen: Amino acids NGAEDESAEAFPLEF from human ACTH was used as the immunogen for the recombinant ACTH antibody. This sequence is from the CLIP or Corticotropin-like intermediary peptide polypeptide of ACTH.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the recombinant ACTH antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the recombinant ACTH antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for ACTH

Target: ACTH (Adrenocorticotropic hormone (ACTH))

Alternative Name: ACTH

Background: POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into ten hormone chains named NPP, ACTH, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress. Anti-ACTH is a useful marker in classification of pituitary tumors and the study of pituitary disease. It reacts with ACTH-producing cells (corticotrophs). It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

UniProt: P01189

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity