Recombinant MAP2 antibody (pSer136)

Catalog No. ABIN7879708

The Rabbit Monoclonal anti-MAP2 antibody (Clone 32M37) (ABIN7879708) specifically detects MAP2 in WB, IHC, ICC and IF. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant MAP2 antibody (pSer136) (ABIN7879708)

Target: MAP2 (Microtubule-Associated Protein 2 (MAP2))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MAP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: 32M37

Product Details anti-MAP2 Antibody

Binding Specificity: pSer136

Purpose: Phospho-MAP2 (Ser136) Antibody / Microtubule-associated protein 2

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Phospho-MAP2 (S136) was used as the immunogen for the Phospho-MAP2 (Ser136) antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Phospho-MAP2 (Ser136) antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the Phospho-MAP2 (Ser136) antibody at -20oC.

Target Details for MAP2

Target: MAP2 (Microtubule-Associated Protein 2 (MAP2))

Alternative Name: MAP2

Background: Phospho-MAP2 (Ser136) antibody detects microtubule-associated protein 2 (MAP2) when phosphorylated at serine 136. MAP2 is a neuronal cytoskeletal protein that stabilizes microtubules and contributes to dendritic architecture, synaptic plasticity, and neuronal signaling. Phosphorylation at Ser136, mediated by kinases such as PKA and CaMKII, modulates MAP2's ability to bind microtubules and regulate cytoskeletal dynamics.

Research using Phospho-MAP2 (Ser136) antibody has demonstrated its importance in neuronal development and function. Phosphorylation at Ser136 reduces MAP2's affinity for microtubules, promoting reorganization of dendritic structures. This regulation is critical during synaptogenesis, axon guidance, and activity-dependent plasticity. In models of learning and memory, changes in Ser136 phosphorylation correlate with synaptic remodeling and behavioral adaptation.

In neurodegenerative disease, dysregulated MAP2 phosphorylation contributes to cytoskeletal instability and neuronal dysfunction. Aberrant phosphorylation patterns are observed in Alzheimer's disease, Parkinson's disease, and traumatic brain injury, where MAP2 loss or mislocalization signals neuronal damage. Monitoring Ser136 phosphorylation provides insights into neuronal health and disease progression.

MAP2 phosphorylation also influences interactions with signaling molecules and cytoskeletal regulators. By modulating dendritic morphology, phospho-MAP2 contributes to long-term potentiation and depression, essential processes underlying cognition. Altered Ser136 phosphorylation has been linked to psychiatric conditions, including schizophrenia and depression, where synaptic dysfunction is a hallmark.

Antibodies against phospho-MAP2 (Ser136) are validated for immunohistochemistry, immunofluorescence, and western blot. These reagents selectively detect the phosphorylated form, distinguishing it from total MAP2. Clone-based antibodies ensure reproducibility and specificity in complex neuronal systems.

NSJ Bioreagents supplies this Phospho-MAP2 (Ser136) antibody for studies in neurodevelopment, synaptic plasticity, and neurodegenerative disease.

UniProt: P11137