Recombinant ALDH2 antibody

Catalog No. ABIN7879942

The Rabbit Monoclonal anti-ALDH2 antibody (Clone 31A72) (ABIN7879942) specifically detects ALDH2 in WB. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Recombinant ALDH2 antibody (ABIN7879942)

Target: ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ALDH2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 31A72

Product Details anti-ALDH2 Antibody

Purpose: ALDH2 Antibody / Aldehyde dehydrogenase 2

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human ALDH2 was used as the immunogen for the ALDH2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ALDH2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the ALDH2 antibody at -20oC.

Target Details for ALDH2

Target: ALDH2 (Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2))

Alternative Name: ALDH2

Background: ALDH2 antibody detects aldehyde dehydrogenase 2, a mitochondrial enzyme that catalyzes the oxidation of acetaldehyde and other toxic aldehydes into less reactive carboxylic acids. ALDH2 belongs to the aldehyde dehydrogenase superfamily and is highly expressed in liver, heart, and skeletal muscle. It plays a crucial role in alcohol metabolism, detoxification of lipid peroxidation products, and protection against oxidative stress.

Research using ALDH2 antibody has revealed the enzyme's central importance in human health. ALDH2 metabolizes acetaldehyde generated during ethanol metabolism, preventing toxic accumulation that causes alcohol flushing and tissue damage. A common polymorphism, ALDH2*2, prevalent in East Asian populations, reduces enzymatic activity and leads to heightened acetaldehyde sensitivity. This variant is associated with increased risk of esophageal cancer, cardiovascular disease, and alcohol intolerance.

Beyond alcohol metabolism, ALDH2 detoxifies reactive aldehydes such as 4-hydroxynonenal (4-HNE) and malondialdehyde, protecting cells from oxidative damage. Reduced ALDH2 activity increases susceptibility to ischemic injury, neurodegeneration, and metabolic disorders. In cardiovascular research, ALDH2 has been shown to protect against myocardial infarction and heart failure by detoxifying aldehydes generated during ischemic stress. Pharmacological activation of ALDH2 has been investigated as a therapeutic strategy for cardiovascular protection.

In cancer research, altered ALDH2 expression contributes to tumor progression and therapy response. High ALDH activity, often considered a stem cell marker, confers chemoresistance and supports cancer stem cell survival. ALDH2 also intersects with mitochondrial metabolism, influencing cellular redox states and survival pathways.

Antibodies against ALDH2 are validated for western blot, immunohistochemistry, immunofluorescence, and ELISA. These reagents enable detection of mitochondrial localization, quantification of expression, and monitoring of activity under stress conditions. They provide tools for studying alcohol-related disease, cardiovascular protection, and cancer biology.

NSJ Bioreagents provides this ALDH2 antibody for studies in metabolism, toxicology, and mitochondrial biology.

UniProt: P05091