ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) antibody

Catalog No. ABIN7880020

The Rabbit Monoclonal anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B antibody (Clone FDB-1) (ABIN7880020) specifically detects ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B in WB. The antibody is reactive with Human samples.

Quick Overview for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) antibody (ABIN7880020)

Target: ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B)

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Clone: FDB-1

Product Details

Purpose: MDR1 Antibody / P Glycoprotein / ABCB1

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human P Glycoprotein / ABCB1 / MDR1 was used as the immunogen for the MDR1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MDR1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the MDR1 antibody at -20oC.

Target Details

Target: ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B)

Alternative Name: MDR1

Background: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [RefSeq]

UniProt: P08183