BIM antibody

Catalog No. ABIN7880062

The Rabbit Monoclonal anti-BIM antibody (Clone CBE-2) (ABIN7880062) specifically detects BIM in WB, IF and IHC (p). The antibody is reactive with Human samples.

Quick Overview for BIM antibody (ABIN7880062)

Target: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BIM antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CBE-2

Product Details anti-BIM Antibody

Purpose: BCL2L11 Antibody / BIM

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human Bim / BCL2L11 was used as the immunogen for the Bim antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the BCL2L11 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the BCL2L11 antibody at -20oC.

Target Details for BIM

Target: BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Alternative Name: BCL2L11

Background: The protein encoded by the BCL2L11 gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [RefSeq]

UniProt: O43521

Pathways: PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity