BNIP3L/NIX antibody

Catalog No. ABIN7880065

The Rabbit Monoclonal anti-BNIP3L/NIX antibody (Clone ABIB-2) (ABIN7880065) specifically detects BNIP3L/NIX in WB. The antibody is reactive with Human samples.

Quick Overview for BNIP3L/NIX antibody (ABIN7880065)

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This BNIP3L/NIX antibody is un-conjugated

Application: Western Blotting (WB)

Clone: ABIB-2

Product Details anti-BNIP3L/NIX Antibody

Purpose: Nix Antibody / BNIP3L

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human Nix / BNIP3L was used as the immunogen for the Nix antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Nix antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the Nix antibody at -20oC.

Target Details for BNIP3L/NIX

Target: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Alternative Name: Nix

Background: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like' (BNIP3L), also called NIP3-like protein X (Nix) induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. [UniProt]

UniProt: O60238

Pathways: Autophagy