Recombinant CABP1 antibody

Catalog No. ABIN7880136

The Rabbit Monoclonal anti-CABP1 antibody is suitable to detect CABP1 in samples from Human and Mouse. It has been validated for WB, ICC and IF.

Quick Overview for Recombinant CABP1 antibody (ABIN7880136)

Target: CABP1 (Calcium Binding Protein 1 (CABP1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CABP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: 31C60

Product Details anti-CABP1 Antibody

Purpose: CABP1 Antibody / Calcium binding protein 1

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human CABP was used as the immunogen for the CABP1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CABP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the CABP1 antibody at -20oC.

Target Details for CABP1

Target: CABP1 (Calcium Binding Protein 1 (CABP1))

Alternative Name: CABP1

Background: CABP1 antibody detects calcium binding protein 1, a neuronal calcium binding protein encoded by the CABP1 gene. CABP1 belongs to the calmodulin like protein family and contains EF hand domains that sense calcium signals. It regulates calcium channels, neurotransmitter release, and synaptic plasticity. CABP1 is predominantly expressed in brain and retina, where it modulates signaling events essential for neuronal communication and vision.

CABP1 antibody is widely used in neuroscience and sensory biology research. CABP1 interacts with L type calcium channels and inositol 1,4,5 triphosphate receptors, tuning calcium signaling in neurons. It plays roles in learning, memory, and synaptic adaptation. In the retina, CABP1 modulates photoreceptor signaling and contributes to visual processing. By detecting CABP1, researchers can evaluate how neuronal calcium sensors shape cellular signaling.

In western blot assays, CABP1 antibody detects protein bands corresponding to expected isoforms in neural tissue. Immunohistochemistry highlights expression in hippocampus and retina, while immunofluorescence reveals subcellular localization at synapses and dendrites. These methods support detailed analysis of calcium binding proteins in neurons.

Altered CABP1 expression has been linked to neurological disorders including schizophrenia and epilepsy, where calcium signaling is disrupted. CABP1 also influences neuronal excitability and response to stress, suggesting broader roles in neuroprotection. By applying CABP1 antibody, scientists can investigate how calcium sensors contribute to brain function and disease mechanisms.

CABP1 antibody from NSJ Bioreagents offers strong specificity for detecting calcium binding protein 1 across tissues. Its reliable performance across multiple applications ensures accurate results, supporting research into calcium regulation in neural signaling and vision.

UniProt: Q9NZU7

Pathways: Synaptic Membrane, Negative Regulation of Transporter Activity