Recombinant Caspase 6 antibody

Catalog No. ABIN7880193

The Rabbit Monoclonal anti-Caspase 6 antibody is suitable to detect Caspase 6 in samples from Human, Mouse and Rat. It has been validated for WB and IHC.

Quick Overview for Recombinant Caspase 6 antibody (ABIN7880193)

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Caspase 6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 31C93

Product Details anti-Caspase 6 Antibody

Purpose: CASP6 Antibody / Caspase 6

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human Caspase-6 was used as the immunogen for the CASP6 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CASP6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the CASP6 antibody at -20oC.

Target Details for Caspase 6

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Alternative Name: CASP6

Background: CASP6 antibody detects caspase 6, a cysteine protease encoded by the CASP6 gene. Alternate identifiers include MCH2 and apoptotic cysteine protease 6. Caspase 6 belongs to the caspase family of cysteine aspartate proteases that orchestrate apoptosis and inflammation. Synthesized as an inactive proenzyme, caspase 6 undergoes autocatalytic processing or cleavage by upstream caspases to generate the active enzyme, which then cleaves specific substrates during programmed cell death.

CASP6 antibody is widely applied in neuroscience, apoptosis research, and oncology. Caspase 6 activity contributes to neuronal apoptosis and axonal degeneration, with elevated activity linked to Alzheimer disease and Huntington disease. In cancer biology, caspase 6 mediates apoptosis in response to stress and chemotherapeutic drugs. By detecting caspase 6, researchers can examine apoptotic pathways and their dysregulation in disease.

Western blot assays identify pro and cleaved caspase 6 isoforms, immunohistochemistry maps expression in tissues undergoing apoptosis, and immunofluorescence detects localization in neuronal and cancer cell models. These assays provide robust methods for analyzing apoptotic signaling pathways.

Caspase 6 cleaves substrates such as lamin A and huntingtin, contributing to nuclear disassembly and neurodegeneration. Dysregulated activity promotes pathological cell death, while insufficient activity may contribute to impaired apoptosis in cancer. By applying CASP6 antibody, scientists can evaluate the balance of pro survival and pro death signals across systems.

CASP6 antibody from NSJ Bioreagents delivers reliable specificity for detecting caspase 6. Its performance across multiple applications supports both basic apoptosis research and translational studies in oncology and neurodegeneration.

UniProt: P55212

Pathways: Apoptosis, Caspase Cascade in Apoptosis