Recombinant CD247 antibody

Catalog No. ABIN7880264

This Rabbit Monoclonal antibody specifically detects CD247 in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant CD247 antibody (ABIN7880264)

Target: CD247 (CD247 Molecule (CD247))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD247 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IHI-3

Product Details anti-CD247 Antibody

Purpose: CD247 Antibody / CD3 zeta

Purification: Affinity chromatography

Immunogen: A peptide sequence specific to CD3 zeta protein was used as the immunogen for the CD247 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CD247 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CD247 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CD247

Target: CD247 (CD247 Molecule (CD247))

Alternative Name: CD247

Background: CD247 (CD3 zeta) is a key signaling component of the T cell receptor (TCR) complex, essential for antigen recognition and T cell activation. It contains multiple immunoreceptor tyrosine-based activation motifs (ITAMs) that initiate downstream signaling cascades upon antigen engagement, leading to T cell proliferation and differentiation.

CD247 is predominantly expressed in T cells and natural killer (NK) cells, where it regulates immune responses against pathogens and abnormal cells. Alterations in CD247 expression or function have been linked to immunodeficiencies, autoimmune diseases, and cancer, making it a valuable focus for immunological research.

Using a high-quality CD247 antibody enables precise detection in applications such as western blot, flow cytometry, and immunohistochemistry. A CD247 antibody from NSJ Bioreagents ensures reproducibility and sensitivity for studies in T cell biology, immune signaling, and disease pathogenesis. Selecting the right CD247 antibody is essential for producing accurate and consistent research results.

UniProt: P20963

Pathways: TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway