CD72 antibody

Catalog No. ABIN7880344

The Mouse Monoclonal anti-CD72 antibody (Clone BU40) (ABIN7880344) specifically detects CD72 in FACS and IHC (p). The antibody is reactive with Human samples.

Quick Overview for CD72 antibody (ABIN7880344)

Target: CD72 (CD72 Molecule (CD72))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD72 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: BU40

Product Details anti-CD72 Antibody

Purpose: CD72 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: The HF B1 plasmacytoid cell line was used as the immunogen for this CD72 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the CD72 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the CD72 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for CD72

Target: CD72 (CD72 Molecule (CD72))

Alternative Name: CD72

Background: CD5 has been identified as a transmembrane glycoprotein that is expressed on 70 % of normal peripheral blood lymphocytes and on virtually all T lymphocytes in thymus and peripheral blood. Activation of T cells through the T cell receptor (TCR) results in tyrosine phosphorylation of CD5, and the absence of CD5 renders T cells hyper-responsive to TCR-mediated activation. CD5 associates with the TCR/CD3 chain, and with the Src family kinase, Lck p56. The C-type lectin superfamily member CD72 is a cell surface negative regulator of B cell activation from the pro-B through the mature B cell stage. CD72 serves as a receptor for CD5. The ability of lymphocytes to respond to antigenic or mitogenic stimulation utilizes both positive and negative regulatory proteins that influence the threshold for responsiveness. The human CD72 gene maps to chromosome 9p13.3 and encodes a transmembrane glycoprotein that contains an ITIM. Upon tyrosine phosphorylation, the CD72 ITIM recruits SH2-containing phosphatases such as SHP-1, resulting in downregulation of cell activation. CD72-/- mice contain hyperproliferative B cells.

UniProt: P21854

Pathways: BCR Signaling