Recombinant COL2 antibody

Catalog No. ABIN7880474

This Rabbit Monoclonal antibody specifically detects COL2 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant COL2 antibody (ABIN7880474)

Target: COL2 (Collagen, Type II (COL2))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This COL2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: COL2A1-8810R

Product Details anti-COL2 Antibody

Purpose: Collagen II Antibody

Purification: Protein A/G affinity

Immunogen: Bovine collagen type II (CII) was used as the immunogen for the Collagen II antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Collagen II antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Collagen II antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for COL2

Target: COL2 (Collagen, Type II (COL2))

Alternative Name: Collagen II

Background: The extensive family of COL gene products (collagens) is composed of several chain types, including fibril-forming interstitial collagens (types I, II, III and V) and basement membrane collagens (type IV), each type containing multiple isoforms. Collagens are fibrous, extracellular matrix proteins with high tensile strength and are the major components of connective tissue, such as tendons and cartilage. All collagens contain a triple helix domain and frequently show lateral self-association in order to form complex connective tissues. Several collagens also play a role in cell adhesion, important for maintaining normal tissue architecture and function. In cartilage, Collagen Type II constitutes the bulk of the fibril. Sensitization with Collagen Type II induces an erosive polyarthritis in rats, mice and higher primates which can resemble rheumatoid arthritis and relapsing polychrondritis.

UniProt: P02458