Recombinant Cyclin H antibody

Catalog No. ABIN7880529

The Rabbit Monoclonal anti-Cyclin H antibody is suitable to detect Cyclin H in samples from Human. It has been validated for WB.

Quick Overview for Recombinant Cyclin H antibody (ABIN7880529)

Target: Cyclin H (CCNH)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Cyclin H antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 28C49

Product Details anti-Cyclin H Antibody

Purpose: CCNH Antibody / Cyclin H

Purification: Affinity chromatography

Immunogen: A synthetic peptide derived from human Cyclin H/p34 was used as the immunogen for the CCNH antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CCNH antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the CCNH antibody at -20oC.

Target Details for Cyclin H

Target: Cyclin H (CCNH)

Alternative Name: CCNH

Background: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. [UniProt]

UniProt: P51946

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases, M Phase