Recombinant Endoglin antibody

Catalog No. ABIN7880681

This Mouse Monoclonal antibody specifically detects Endoglin in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant Endoglin antibody (ABIN7880681)

Target: Endoglin (ENG)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Endoglin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ENG-8961R

Product Details anti-Endoglin Antibody

Purpose: CD105 Antibody / Endoglin

Purification: Protein A/G affinity

Immunogen: A recombinant fragment of human Endoglin protein was used as the immunogen for the CD105 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the CD105 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CD105 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Endoglin

Target: Endoglin (ENG)

Alternative Name: CD105

Background: CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.

UniProt: P17813